Rest in peace FTDP-17

Refining frontotemporal dementia with parkinsonism linked to chromosome 17: introducing FTDP-17 (MAPT) and FTDP-17 (PGRN).

Frontotemporal dementia with parkinsonism (FTDP) is a major neurodegenerative syndrome, particularly for those with symptoms beginning before age 65 years. A spectrum of degenerative disorders can present as sporadic or familial FTDP. Mutations in the gene encoding the microtubule-associated protein tau (MAPT; OMIM +157140) on chromosome 17 have been found in many kindreds with familial FTDP. S...

Terri Schiavo: rest in peace.

As Charles Weijer has pointed out, the case of Terri Schiavo involved a family conflict regarding end-of-life decisionmaking. This irreconcilable conflict resulted in a series of judicial interventions that were a rerun, with some differences, of the Karen Ann Quinlan, Nancy Beth Cruzan and other wellknown cases. Nowadays, many hospitals rely on clinical ethicists, ethics committees or mediator...

NEUROLOGICAL REVIEW Refining Frontotemporal Dementia With Parkinsonism Linked to Chromosome 17 Introducing FTDP-17 (MAPT) and FTDP-17 (PGRN)

F rontotemporal dementia with parkinsonism (FTDP) is a major neurodegenerative syndrome, particularly for those with symptoms beginning before age 65 years. A spectrum of degenerative disorders can present as sporadic or familial FTDP. Mutations in the gene encoding the microtubule-associated protein tau (MAPT; OMIM 157140) on chromosome 17 have been found in many kindreds with familial FTDP. S...

Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) Authors: Doctors

Keywords Disease name Excluded diseases Diagnosis criteria / definition Differential diagnosis Frequency Clinical description Laboratory findings Management including treatment Etiology Diagnostic methods Genetic counseling Keywords References Abstract Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is an autosomal dominant neurodegenerative disorder caused by mutatio...

The National Pharmaceuticals Strategy: Rest in peace, revive or renew?